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Literature summary for 3.4.24.86 extracted from
- TNF-alpha-converting enzyme cleaves the macrophage colony-stimulating factor receptor in macrophages undergoing activation (2001), J. Immunol., 166, 1583-1589.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1,10-phenanthroline | - |
Homo sapiens |  |
| 1,10-phenanthroline | - |
Mus musculus | |
| BB 2116 | - |
Homo sapiens | |
| BB2275 | - |
Mus musculus | |
| BB2284 | - |
Mus musculus | |
| BB3103 | - |
Homo sapiens | |
| Hydroxamate | - |
Homo sapiens | |
| Hydroxamate | - |
Mus musculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
BAC-1.2F5 immortalized by transfection with replication-deficient SV40 DNA | - |
| Mus musculus | - |
Dexter-ras-myc cell line | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| bone marrow | - |
Mus musculus | - |
| bone marrow | - |
Homo sapiens | - |
| fibroblast | - |
Mus musculus | - |
| fibroblast | - |
Homo sapiens | - |
| macrophage | - |
Mus musculus | - |
| macrophage | - |
Homo sapiens | - |
| spleen | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| beta-amyloid precursor protein + H2O | Alzheimer amyloid precursor protein | Homo sapiens | ? | - |
? | |
| macrophage colony-stimulating factor receptor M-CSFR + H2O | - |
Homo sapiens | ? | - |
? | |
| proTNF-alpha + H2O | - |
Mus musculus | soluble TNF-alpha | - |
? | |
| proTNF-alpha + H2O | - |
Homo sapiens | soluble TNF-alpha | - |
? | |
| transforming growth factor alpha + H2O | - |
Mus musculus | ? | - |
? | |
| transforming growth factor alpha + H2O | - |
Homo sapiens | ? | - |
? | |
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Release 2023.1 (January 2023)
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